Ebook Biophysics: Searching for Principles
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Biophysics: Searching for Principles
Ebook Biophysics: Searching for Principles
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Interactions between the fields of physics and biology reach back over a century, and some of the most significant developments in biology--from the discovery of DNA's structure to imaging of the human brain--have involved collaboration across this disciplinary boundary. For a new generation of physicists, the phenomena of life pose exciting challenges to physics itself, and biophysics has emerged as an important subfield of this discipline. Here, William Bialek provides the first graduate-level introduction to biophysics aimed at physics students.Bialek begins by exploring how photon counting in vision offers important lessons about the opportunities for quantitative, physics-style experiments on diverse biological phenomena. He draws from these lessons three general physical principles--the importance of noise, the need to understand the extraordinary performance of living systems without appealing to finely tuned parameters, and the critical role of the representation and flow of information in the business of life. Bialek then applies these principles to a broad range of phenomena, including the control of gene expression, perception and memory, protein folding, the mechanics of the inner ear, the dynamics of biochemical reactions, and pattern formation in developing embryos.Featuring numerous problems and exercises throughout, Biophysics emphasizes the unifying power of abstract physical principles to motivate new and novel experiments on biological systems.Covers a range of biological phenomena from the physicist's perspectiveFeatures 200 problemsDraws on statistical mechanics, quantum mechanics, and related mathematical conceptsIncludes an annotated bibliography and detailed appendixes
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Product details
Hardcover: 640 pages
Publisher: Princeton University Press (October 28, 2012)
Language: English
ISBN-10: 9780691138916
ISBN-13: 978-0691138916
ASIN: 0691138915
Product Dimensions:
8.5 x 2 x 10 inches
Shipping Weight: 4.4 pounds (View shipping rates and policies)
Average Customer Review:
4.7 out of 5 stars
4 customer reviews
Amazon Best Sellers Rank:
#913,465 in Books (See Top 100 in Books)
This book lives up to both the reviews of others and the stated aims of the author. The goal is to arrive at and use concepts, not merely to describe biological systems. One must have a physical science background to really appreciate the content of this book. It's not a book for biologists, unless they want to really work at learning how a physical scientist or specialist in biophysics might approach the subject. The book assumes a familiarity witch concepts from areas such as statistical mechanics, thermodynamics, relevant math and information theory. One does not have to be an expert in this background material to profit from this text. However, general familiarity with background topics is useful. The book has appendices, which help a bit for those with less than a deep knowledge of background topics.
If you are not versed in Physics you will not get through this book
The aim of the author, Dr. William Bialek of Princeton University, is that of searching for the principles of a theoretical physics of biological systems (in short, theoretical biophysics). Accordingly, this can be done by employing (mainly) the concepts of statistical mechanics together with a good knowledge of biology, its complex structures, and relevant experiments. The search takes the form of a tour whereby in many places the author speaks directly to the reader (for example, page 265: "To appreciate this approach you need to know...."). After an introductory chapter (Ch.1), the tour takes off at Chapter 2 with the biophysics of photon counting processes of human vision. Early physiology experiments carried out in the 1940s are discussed in great detail as well as the 3D structure of the eyes (including those of insects) and rod and cone cells down to the molecular-level workings of the protein rhodopsin and its cofactor (retinal).Next, after a short interlude-summary (Ch. 3), three candidate principles of theoretical biophysics are laid down: the importance of noise in the functioning of biological devices such as the cells of the retina (Ch. 4), the fact that fine tuning of parameters is not important for biological systems (Ch. 5), and the fundamental role of information transfer (Ch. 6). Of the three principles, I must admit that the most challenging and difficult to understand for me is the second, no fine tuning. In principle, biological systems know nothing about parameters, only we know about them when building a mathematical model of a biological phenomena. Hence, it could be that the fine-tuning principle arises from the models themselves but, perhaps, there might be a deeper principle connected to the physical constraints imposed by the biological superstructures (think about the eye) that characterize living organisms. Both scientists as well as the young minds of brilliant students will have to think very deeply about the three principles and contribute their own idea to the field. These candidate principles, therefore, represent a great stimuli for further research.Chapter 7 (Outlook) is followed by an Appendix where further topics (Poisson processes, diffraction and biological structures, maximum entropy, etc.) are discussed in detail. The book is interspersed with 200 problems, many of which require the writing of small computer codes (Matlab is suggested by the author although any high-level language will do), distributed as follows:Ch. 1: 0 problemsCh. 2: 39Ch. 3: 0Ch. 4: 47Ch. 5: 36Ch. 6: 47Ch. 7: 0App. : 31It is obvious that an in-depth, serious study of this 600+ pages tome and solution of its 200 problems will require a lot of effort and time but it is worth spending such time both to the would be theoretical biophysicist and to professional scientists (biophysicists or not) with an inclination toward quantitative biology. From this original book one can truly appreciate the approach adopted by a professional physicist toward solving complex biological problems. The book ends with an annotated bibliography where important references about theory and experiments are listed. A complementary book with a traditional exposition of Biophysics is that of Dr. Roland Glaser (now in its 2-nd edition).
The content of this book merits six stars. The author wrote for students of physics and did not hide the mathematics or the physics, which is the usual lamentable practice in books on biophysics.But Princeton University Press turned a fine manuscript into a nearly useless hardcover. PUP used outer margins that are more than two inches wide and inner margins that are scarcely wider than half an inch. The text therefore is crammed into the gutter. Readers must follow each line of text as it curves and dives into the spine of the book.To make matters worse, the book weighs 4.4 pounds. This heft may be fine for sumo wrestlers, but it makes reading the book awkward.People should avoid the hardcover edition and buy instead an e-book edition from eBooks.com. The Kindle edition is even worse than the PUP hardcover: the equations are image files which don't scale.
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